Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce interfollicular epidermal hyperplasia and tumor growth

Tumors and associated stroma manifest mechanical properties that promote cancer. Mechanosensation of tissue stiffness activates the Rho/ROCK pathway to increase actomyosin-mediated cellular tension to re-establish force equilibrium. To determine how actomyosin tension affects tissue homeostasis and...

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Main Authors: Samuel, Michael S, Lopez, Jose I, McGhee, Ewan J, Croft, Daniel R, Strachan, David, Timpson, Paul, Munro, June, Schröder, Ewald, Zhou, Jing, Brunton, Valerie G, Barker, Nick, Clevers, Hans, Sansom, Owen J, Anderson, Kurt I, Weaver, Valerie M, Olson, Michael F
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115541/
https://ncbi.nlm.nih.gov/pubmed/21665151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.05.008
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