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Disruption of the Man-6-P Targeting Pathway in Mice Impairs Osteoclast Secretory Lysosome Biogenesis

Osteoclasts are specialized cells that secrete lysosomal acid hydrolases at the site of bone resorption, a process critical for skeletal formation and remodeling. However, the cellular mechanism underlying this secretion and the organization of the endo-lysosomal system of osteoclasts have remained...

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Hlavní autoři: van Meel, Eline, Boonen, Marielle, Zhao, Haibo, Oorschot, Viola, Ross, F. Patrick, Kornfeld, Stuart, Klumperman, Judith
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115509/
https://ncbi.nlm.nih.gov/pubmed/21466643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0854.2011.01203.x
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