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Autophagy proteins regulate the secretory component of osteoclastic bone resorption
Osteoclasts resorb bone via the ruffled border whose complex folds are generated by secretory lysosome fusion with bone-apposed plasma membrane. Lysosomal fusion with the plasmalemma results in acidification of the resorptive microenvironment and release of CatK to digest the organic matrix of bone....
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3244473/ https://ncbi.nlm.nih.gov/pubmed/22055344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.08.016 |
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