Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes

Recent data indicate that sustained elevations in plasma insulin suppress the mRNA for IRS-2, a component of the insulin signaling pathway in liver, and that this deficiency contributes to hepatic insulin resistance and inappropriate gluconeogenesis. Here, we use nuclear run-on assays to show that i...

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Hauptverfasser: Zhang, Jiandi, Ou, Jiafu, Bashmakov, Yuriy, Horton, Jay D., Brown, Michael S., Goldstein, Joseph L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2001
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC31125/
https://ncbi.nlm.nih.gov/pubmed/11259670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.071054598
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