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A simplified synthesis of novel dictyostatin analogs with in vitro activity against epothilone B resistant cells and antiangiogenic activity in zebrafish embryos

The natural product (−)-dictyostatin is a microtubule stabilizing agent that potently inhibits the growth of human cancer cells including paclitaxel-resistant clones. Extensive structure-activity relationship studies have revealed several regions of the molecule that could be altered without loss of...

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Detalhes bibliográficos
Main Authors: Vollmer, Laura L., Jiménez, Maria, Camarco, Daniel P., Zhu, Wei, Daghestani, Hikmat N., Balachandran, Raghavan, Reese, Celeste E., Lazo, John S., Hukriede, Neil A., Curran, Dennis P., Day, Billy W., Vogt, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3112307/
https://ncbi.nlm.nih.gov/pubmed/21490306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-1048
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