IMMUNE DYSREGULATION BY THE RHEUMATOID ARTHRITIS SHARED EPITOPE

Rheumatoid arthritis (RA) is closely associated with HLA-DRB1 alleles that code a five-amino acid sequence motif in positions 70–74 of the HLA-DRβ chain, called the shared epitope (SE). The mechanistic basis of SE-RA association is unknown. We have recently found that the SE functions as an allele-s...

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Main Authors: De Almeida, Denise E., Ling, Song, Pi, Xiujun, Hartmann-Scruggs, Anne M., Pumpens, Paul, Holoshitz, Joseph
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111926/
https://ncbi.nlm.nih.gov/pubmed/20592276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0904002
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