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A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion
We previously proposed that POT1 prevents ATR signaling at telomeres by excluding RPA from the single-stranded TTAGGG repeats. Here we use a Shld1-stabilized degron-POT1a fusion (DD-POT1a) to study the telomeric ATR kinase response. In the absence of Shld1, DD-POT1a degradation resulted in rapid and...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3111920/ https://ncbi.nlm.nih.gov/pubmed/21070964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.10.016 |
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