Nuclear Export of the NF-κB Inhibitor IκBα Is Required for Proper B Cell and Secondary Lymphoid Tissue Formation

The N-terminal nuclear export sequence (NES) of inhibitor of nuclear factor kappa B (NF-κB) alpha (IκBα) promotes NF-κB export from the cell nucleus to the cytoplasm, but the physiological role of this export regulation remains unknown. Here we report the derivation and analysis of genetically targe...

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Main Authors: Wuerzberger-Davis, Shelly M., Chen, Yuhong, Yang, David T., Kearns, Jeffrey D., Bates, Paul W., Lynch, Candace, Ladell, Nicholas C., Yu, Mei, Podd, Andrew, Zeng, Hu, Huang, Tony T., Wen, Renren, Hoffmann, Alexander, Wang, Demin, Miyamoto, Shigeki
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111750/
https://ncbi.nlm.nih.gov/pubmed/21333553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.01.014
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