Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells

Hedgehog (Hh) signaling is critical to the patterning and development of a variety of organ systems, and both ligand-dependent and ligand-independent Hh pathway activation are known to promote tumorigenesis. Recent studies have shown that in tumors promoted by Hh ligands, activation occurs within th...

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Detalhes bibliográficos
Main Authors: Chen, Weiwei, Tang, Tracy, Eastham-Anderson, Jeff, Dunlap, Debra, Alicke, Bruno, Nannini, Michelle, Gould, Stephen, Yauch, Robert, Modrusan, Zora, DuPree, Kelly J., Darbonne, Walter C., Plowman, Greg, de Sauvage, Frederic J., Callahan, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111273/
https://ncbi.nlm.nih.gov/pubmed/21597001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017945108
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