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Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

The Hedgehog (Hh) pathway has been implicated in pancreatic cancer but its role remains controversial. To delineate the cell populations able to respond to Hh ligand stimulation, we expressed an oncogenic allele of Smoothened (SmoM2) to cell autonomously activate Hh signaling in the mouse pancreas....

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Detalles Bibliográficos
Main Authors: Tian, Hua, Callahan, Christopher A., DuPree, Kelly J., Darbonne, Walter C., Ahn, Christina P., Scales, Suzie J., de Sauvage, Frederic J.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2647977/
https://ncbi.nlm.nih.gov/pubmed/19246386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813203106
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