Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site

Proper hedgehog (Hh) signaling is crucial for embryogenesis and tissue regeneration. Dysregulation of this pathway is associated with several types of cancer. The monoclonal antibody 5E1 is a Hh pathway inhibitor that has been extensively used to elucidate vertebrate Hh biology due to its ability to...

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Detalhes bibliográficos
Main Authors: Maun, Henry R., Wen, Xiaohui, Lingel, Andreas, de Sauvage, Frederic J., Lazarus, Robert A., Scales, Suzie J., Hymowitz, Sarah G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924095/
https://ncbi.nlm.nih.gov/pubmed/20504762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.112284
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