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Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site
Proper hedgehog (Hh) signaling is crucial for embryogenesis and tissue regeneration. Dysregulation of this pathway is associated with several types of cancer. The monoclonal antibody 5E1 is a Hh pathway inhibitor that has been extensively used to elucidate vertebrate Hh biology due to its ability to...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2924095/ https://ncbi.nlm.nih.gov/pubmed/20504762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.112284 |
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