Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding

Brain-specific carnitine palmitoyltransferase-1 (CPT-1c) is implicated in CNS control of food intake. In this article, we explore the role of hypothalamic CPT-1c in leptin's anorexigenic actions. We first show that adenoviral overexpression of CPT-1c in hypothalamic arcuate nucleus of rats incr...

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Main Authors: Gao, Su, Zhu, Guangjing, Gao, Xuefei, Wu, Donghai, Carrasco, Patricia, Casals, Núria, Hegardt, Fausto G., Moran, Timothy H., Lopaschuk, Gary D.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111271/
https://ncbi.nlm.nih.gov/pubmed/21593415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1103267108
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