Long-Term Increased Carnitine Palmitoyltransferase 1A Expression in Ventromedial Hypotalamus Causes Hyperphagia and Alters the Hypothalamic Lipidomic Profile

Lipid metabolism in the ventromedial hypothalamus (VMH) has emerged as a crucial pathway in the regulation of feeding and energy homeostasis. Carnitine palmitoyltransferase (CPT) 1A is the rate-limiting enzyme in mitochondrial fatty acid β-oxidation and it has been proposed as a crucial mediator of...

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Main Authors: Mera, Paula, Mir, Joan Francesc, Fabriàs, Gemma, Casas, Josefina, Costa, Ana S. H., Malandrino, Maria Ida, Fernández-López, José-Antonio, Remesar, Xavier, Gao, Su, Chohnan, Shigeru, Rodríguez-Peña, Maria Sol, Petry, Harald, Asins, Guillermina, Hegardt, Fausto G., Herrero, Laura, Serra, Dolors
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018328/
https://ncbi.nlm.nih.gov/pubmed/24819600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097195
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