Promoter methylation of Wnt5a is associated with microsatellite instability and BRAF V600E mutation in two large populations of colorectal cancer patients

BACKGROUND: In colorectal cancer (CRC), tumour microsatellite instability (MSI) status and CpG island methylator phenotype (CIMP) status are indicators of patient outcome, but the molecular events that give rise to these outcomes remain largely unknown. Wnt5a is a critical regulator of non-canonical...

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Détails bibliographiques
Auteurs principaux: Rawson, J B, Mrkonjic, M, Daftary, D, Dicks, E, Buchanan, D D, Younghusband, H B, Parfrey, P S, Young, J P, Pollett, A, Green, R C, Gallinger, S, McLaughlin, J R, Knight, J A, Bapat, B
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2011
Sujets:
Molecular Diagnostics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111198/
https://ncbi.nlm.nih.gov/pubmed/21587258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.165
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