Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer

BACKGROUND: The activity of the protein kinase Akt is frequently dysregulated in cancer and is an important factor in the growth and survival of tumour cells. Akt activation involves the phosphorylation of two residues: threonine 308 (Thr308) in the activation loop and serine 473 (Ser473) in the C-t...

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Detalhes bibliográficos
Main Authors: Vincent, E E, Elder, D J E, Thomas, E C, Phillips, L, Morgan, C, Pawade, J, Sohail, M, May, M T, Hetzel, M R, Tavaré, J M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111153/
https://ncbi.nlm.nih.gov/pubmed/21505451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.132
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