Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

The dose-limiting side effect of the common colon cancer chemotherapeutic CPT-11 is severe diarrhea caused by symbiotic bacterial β-glucuronidases that reactivate the drug in the gut. We sought to target these enzymes without killing the commensal bacteria essential for human health. Potent bacteria...

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Detalhes bibliográficos
Main Authors: Wallace, Bret D., Wang, Hongwei, Lane, Kimberly T., Scott, John E., Orans, Jillian, Koo, Ja Seol, Venkatesh, Madhukumar, Jobin, Christian, Yeh, Li-An, Mani, Sridhar, Redinbo, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3110694/
https://ncbi.nlm.nih.gov/pubmed/21051639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1191175
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