Pharmacologic Targeting of Bacterial β-Glucuronidase Alleviates Nonsteroidal Anti-Inflammatory Drug-Induced Enteropathy in Mice

Small intestinal mucosal injury is a frequent adverse effect caused by nonsteroidal anti-inflammatory drugs (NSAIDs). The underlying mechanisms are not completely understood, but topical (luminal) effects have been implicated. Many carboxylic acid-containing NSAIDs, including diclofenac (DCF), are m...

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Detalhes bibliográficos
Main Authors: LoGuidice, Amanda, Wallace, Bret D., Bendel, Lauren, Redinbo, Matthew R., Boelsterli, Urs A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336811/
https://ncbi.nlm.nih.gov/pubmed/22328575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.191122
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