LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L

Administration of a single dose of anti-CD40L mAb at the time of allogeneic BM transplantation tolerizes peripheral alloreactive T cells and permits establishment of mixed hematopoietic chimerism in mice. Once engrafted, mixed chimeras are systemically tolerant to donor Ags through a central deletio...

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Bibliographische Detailangaben
Hauptverfasser: Lucas, Carrie L., Workman, Creg J., Beyaz, Semir, LoCascio, Samuel, Zhao, Guiling, Vignali, Dario A. A., Sykes, Megan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2011
Schlagworte:
Immunobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109721/
https://ncbi.nlm.nih.gov/pubmed/21422469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-318675
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