Sequence specificity at targeting double-stranded DNA with a γ-PNA oligomer modified with guanidinium G-clamp nucleobases

γ-PNA, a new class of peptide nucleic acids, promises to overcome previous sequence limitations of double-stranded DNA (dsDNA) targeting with PNA. To check the potential of γ-PNA, we have synthesized a biotinylated, pentadecameric γ-PNA of mixed sequence carrying three guanidinium G-clamp nucleobase...

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Hlavní autoři: Kuhn, Heiko, Sahu, Bichismita, Rapireddy, Srinivas, Ly, Danith H, Frank-Kamenetskii, Maxim D
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2010
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109445/
https://ncbi.nlm.nih.gov/pubmed/21687526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/adna.1.1.12444
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