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Synthesis of optically pure γPNA monomers: a comparative study
We report a systematic study examining two synthetic routes, reductive amination and Mitsunobu coupling, for preparation of chiral γ-peptide nucleic acid (γPNA) monomers and oligomers. We found that the reductive amination route is prone to epimerization, even under mild experimental conditions. The...
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| Publié dans: | Tetrahedron |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6379906/ https://ncbi.nlm.nih.gov/pubmed/30792557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2015.03.052 |
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