Crystal Structure of Chiral γ PNA with Complementary DNA Strand—Insights into the Stability and Specificity of Recognition and Conformational Preorganization

We have determined the structure of a PNA-DNA duplex to 1.7 Å resolution by multiple-wavelength anomalous diffraction on a zinc derivative. This structure represents the first high-resolution view of a hybrid duplex containing a contiguous chiral PNA strand with complete γ-backbone modification (“γP...

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Bibliografiset tiedot
Päätekijät: Yeh, Joanne I., Shivachev, Boris, Rapireddy, Srinivas, Crawford, Matthew J., Gil, Roberto R., Du, Shoucheng, Madrid, Marcela, Ly, Danith H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929025/
https://ncbi.nlm.nih.gov/pubmed/20681704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja907225d
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