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Crystal Structure of Chiral γ PNA with Complementary DNA Strand—Insights into the Stability and Specificity of Recognition and Conformational Preorganization
We have determined the structure of a PNA-DNA duplex to 1.7 Å resolution by multiple-wavelength anomalous diffraction on a zinc derivative. This structure represents the first high-resolution view of a hybrid duplex containing a contiguous chiral PNA strand with complete γ-backbone modification (“γP...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2929025/ https://ncbi.nlm.nih.gov/pubmed/20681704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja907225d |
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