A Klothoβ Variant Mediates Protein Stability and Associates with Colon Transit in Irritable Bowel Syndrome with Diarrhea

BACKGROUND/AIMS: Bile acid (BA) malabsorption of moderate severity is reported in 32% of patients with chronic unexplained diarrhea including diarrhea-predominant IBS (IBS-D). We hypothesize that variants of genes regulating hepatic BA synthesis play a role in IBS-D. METHODS: In 435 IBS and 279 heal...

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Main Authors: Wong, Banny S., Camilleri, Michael, Carlson, Paula J., Guicciardi, Maria E., Burton, Duane, McKinzie, Sanna, Rao, Archana S., Zinsmeister, Alan R., Gores, Gregory J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109206/
https://ncbi.nlm.nih.gov/pubmed/21396369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.02.063
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