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Microsomal Prostaglandin E Synthase-1 Inhibits PTEN and Promotes Experimental Cholangiocarcinogenesis and Tumor Progression
BACKGROUND & AIMS: Microsomal prostaglandin E synthase-1 (mPGES-1) is a rate-limiting enzyme that is coupled with cyclooxygenase-2 (COX-2) in the synthesis of prostaglandin E(2) (PGE(2)). Although COX-2 is involved in development and progression of various human cancers, the role of mPGES-1 in c...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3109169/ https://ncbi.nlm.nih.gov/pubmed/21354147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.02.056 |
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