Genetic and Pharmacological Inhibition of the Ca(2+) Influx Channel TRPC3 Protects Secretory Epithelia from Ca(2+)-Dependent Toxicity

BACKGROUND & AIMS: Excessive Ca(2+) influx mediates many cytotoxic processes, including those associated with autoimmune inflammatory diseases such as acute pancreatitis and Sjögren's syndrome. TRPC3 is a major Ca(2+) influx channel in pancreatic and salivary gland cells. We investigated wh...

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Detalhes bibliográficos
Main Authors: Kim, Min Seuk, Lee, Kyu Pil, Yang, Dongki, Shin, Dong Min, Abramowitz, Joel, Kiyonaka, Shigeki, Birnbaumer, Lutz, Mori, Yasuo, Muallem, Shmuel
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109139/
https://ncbi.nlm.nih.gov/pubmed/21354153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.02.052
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