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NGF and proNGF Regulate Functionally Distinct mRNAs in PC12 Cells: An Early Gene Expression Profiling

The biological activities of NGF and of its precursor proNGF are quite distinct, due to different receptor binding profiles, but little is known about how proNGF regulates gene expression. Whether proNGF is a purely pro-apoptotic molecule and/or simply a “less potent NGF” is still a matter of debate...

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Detalhes bibliográficos
Main Authors: D'Onofrio, Mara, Paoletti, Francesca, Arisi, Ivan, Brandi, Rossella, Malerba, Francesca, Fasulo, Luisa, Cattaneo, Antonino
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109000/
https://ncbi.nlm.nih.gov/pubmed/21677785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020839
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