ProNGF Drives Localized and Cell Selective Parvalbumin Interneuron and Perineuronal Net Depletion in the Dentate Gyrus of Transgenic Mice

ProNGF, the precursor of mature Nerve Growth Factor (NGF), is the most abundant NGF form in the brain and increases markedly in the cortex in Alzheimer's Disease (AD), relative to mature NGF. A large body of evidence shows that the actions of ProNGF and mature NGF are often conflicting, dependi...

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Pubblicato in:Front Mol Neurosci
Autori principali: Fasulo, Luisa, Brandi, Rossella, Arisi, Ivan, La Regina, Federico, Berretta, Nicola, Capsoni, Simona, D'Onofrio, Mara, Cattaneo, Antonino
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5299926/
https://ncbi.nlm.nih.gov/pubmed/28232789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00020
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