Functional Characterization of Human ProNGF and NGF Mutants: Identification of NGF P61SR100E as a “Painless” Lead Investigational Candidate for Therapeutic Applications

BACKGROUND: Nerve Growth Factor (NGF) holds a great therapeutic promise for Alzheimer's disease, diabetic neuropathies, ophthalmic diseases, dermatological ulcers. However, the necessity for systemic delivery has hampered the clinical applications of NGF due to its potent pro-nociceptive action...

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Udgivet i:PLoS One
Main Authors: Malerba, Francesca, Paoletti, Francesca, Bruni Ercole, Bruno, Materazzi, Serena, Nassini, Romina, Coppi, Elisabetta, Patacchini, Riccardo, Capsoni, Simona, Lamba, Doriano, Cattaneo, Antonino
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570711/
https://ncbi.nlm.nih.gov/pubmed/26371475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136425
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