Helios Is Associated with CD4 T Cells Differentiating to T Helper 2 and Follicular Helper T Cells In Vivo Independently of Foxp3 Expression

BACKGROUND: Although in vitro IL-4 directs CD4 T cells to produce T helper 2 (Th2)-cytokines, these cytokines can be induced in vivo in the absence of IL-4-signalling. Thus, mechanism(s), different from the in vitro pathway for Th2-induction, contribute to in vivo Th2-differentiation. The pathway fo...

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Main Authors: Serre, Karine, Bénézech, Cécile, Desanti, Guillaume, Bobat, Saeeda, Toellner, Kai-Michael, Bird, Roger, Chan, Susan, Kastner, Philippe, Cunningham, Adam F., MacLennan, Ian C. M., Mohr, Elodie
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108993/
https://ncbi.nlm.nih.gov/pubmed/21677778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020731
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