IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro, but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo

While IL-4 directs CD4 T cells to produce Th2 cytokines (including IL-4, IL-13, IL-5) in vitro it has been shown that production of these cytokines can be induced in vivo in the absence of IL-4/IL-13/STAT-6 signaling. The present report shows that CD8 as well as CD4 T cells activated through their T...

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Bibliographic Details
Main Authors: Serre, Karine, Mohr, Elodie, Gaspal, Fabrina, Lane, Peter J.L., Bird, Roger, Cunningham, Adam F., MacLennan, Ian C.M.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826121/
https://ncbi.nlm.nih.gov/pubmed/20392496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2010.03.010
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