IFN-γ produced by CD8 T cells induces T-bet–dependent and –independent class switching in B cells in responses to alum-precipitated protein vaccine

Alum-precipitated protein (alum protein) vaccines elicit long-lasting neutralizing antibody responses that prevent bacterial exotoxins and viruses from entering cells. Typically, these vaccines induce CD4 T cells to become T helper 2 (Th2) cells that induce Ig class switching to IgG1. We now report...

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Detalhes bibliográficos
Main Authors: Mohr, Elodie, Cunningham, Adam F., Toellner, Kai-Michael, Bobat, Saeeda, Coughlan, Ruth E., Bird, Roger A., MacLennan, Ian C. M., Serre, Karine
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951392/
https://ncbi.nlm.nih.gov/pubmed/20855629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004879107
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