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On the Synthesis of Conformationally Modified Peptides Through Isonitrile Chemistry: Implications for Dealing with Polypeptide Aggregation
A method has been developed to introduce a dimethyleneoxy constraint joining the nitrogen atoms of two consecutive amino acids in the context of a polypeptide. Such a constraint can profoundly affect the tendency of a polypeptide to suffer aggregation and desolubilization. The constraint is readily...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3108857/ https://ncbi.nlm.nih.gov/pubmed/21539308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2023898 |
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