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Total Synthesis of Cyclosporine: Access to N-Methylated Peptides via Isonitrile Coupling Reactions
[Image: see text] Recent developments in the use of isonitriles to furnish secondary and tertiary amide bond formations are applied to a novel total synthesis of the important cyclic polypeptide cyclosporine A. Specifically, the disclosed synthetic route demonstrates the utility of microwave-mediate...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2844917/ https://ncbi.nlm.nih.gov/pubmed/20199071 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja100517v |
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