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Normal Atmospheric Oxygen Tension and the Use of Antioxidants Improve Hepatocyte Spheroid Viability and Function

BACKGROUND: Hepatocyte spheroids have been proposed for drug metabolism studies and in bioartificial liver devices. However, the optimal conditions required to meet the aerobic demands of mitochondria-rich hepatocyte spheroids is not well studied. We hypothesized that an optimal concentration of oxy...

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Autores principales: Lillegard, Joseph B., Fisher, James E., Nedredal, Geir, Luebke-Wheeler, Jennifer, Bao, Ji, Wang, William, Amoit, Bruce, Nyberg, Scott L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107922/
https://ncbi.nlm.nih.gov/pubmed/21302300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22651
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