Shortening Infusion Time for High-Dose Methotrexate Alters Antileukemic Effects: A Randomized Prospective Clinical Trial

PURPOSE: To determine whether shortening the infusion duration of high-dose methotrexate (HDMTX; 1 g/m(2)) affects the in vivo accumulation of active methotrexate polyglutamates (MTXPG(1-7)) in leukemia cells and whether this differs among major acute lymphoblastic leukemia (ALL) subtypes. METHODS:...

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Bibliographic Details
Main Authors: Mikkelsen, Torben S., Sparreboom, Alex, Cheng, Cheng, Zhou, Yinmei, Boyett, James M., Raimondi, Susana C., Panetta, John C., Bowman, W. Paul, Sandlund, John T., Pui, Ching-Hon, Relling, Mary V., Evans, William E.
Format: Artigo
Language:Inglês
Published: American Society of Clinical Oncology 2011
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Original Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107765/
https://ncbi.nlm.nih.gov/pubmed/21444869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.32.5340
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