Evaluation of the novel mitotic modulator ON 01910.Na in pancreatic cancer and preclinical development of an ex vivo predictive assay

The pupose of this study was to evaluate the activity of ON 01910.Na, a mitotic inhibitor, in in vitro and in vivo models of pancreatic cancer and to discover biomarkers predictive of efficacy. Successive in vitro and in vivo models were used; these included cell line-derived and patient-derived tum...

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Detalhes bibliográficos
Main Authors: Jimeno, A, Chan, A, Cusatis, G, Zhang, X, Wheelhouse, J, Solomon, A, Chan, F, Zhao, M, Cosenza, SC, Reddy, MV Ramana, Rudek, MA, Kulesza, P, Donehower, RC, Reddy, EP, Hidalgo, M
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107737/
https://ncbi.nlm.nih.gov/pubmed/19029951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.424
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