Evaluation of the novel mitotic modulator ON 01910.Na in pancreatic cancer and preclinical development of an ex vivo predictive assay

The pupose of this study was to evaluate the activity of ON 01910.Na, a mitotic inhibitor, in in vitro and in vivo models of pancreatic cancer and to discover biomarkers predictive of efficacy. Successive in vitro and in vivo models were used; these included cell line-derived and patient-derived tum...

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Main Authors: Jimeno, A, Chan, A, Cusatis, G, Zhang, X, Wheelhouse, J, Solomon, A, Chan, F, Zhao, M, Cosenza, SC, Reddy, MV Ramana, Rudek, MA, Kulesza, P, Donehower, RC, Reddy, EP, Hidalgo, M
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107737/
https://ncbi.nlm.nih.gov/pubmed/19029951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.424
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