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Thermodynamic compensation upon binding to exosite 1 and the active site of thrombin
Several lines of experimental evidence including amide exchange and NMR suggest that ligands binding to thrombin cause reduced backbone dynamics. Binding of the covalent inhibitor dPhe-Pro-Arg chloromethylketone to the active site serine, as well as non-covalent binding of a fragment of the regulato...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3107735/ https://ncbi.nlm.nih.gov/pubmed/21526769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2004069 |
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