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Evidence for common structural changes in thrombin induced by active-site or exosite binding.

The gamma-loop of thrombin is a flexible, surface-accessible loop in free thrombin that appears to be one of several sites participating in the interaction of the enzyme with macromolecular substrates and inhibitors. Using limited proteolysis and intrinsic fluorescence measurements, we have studied...

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Detalhes bibliográficos
Main Authors: Parry, M A, Stone, S R, Hofsteenge, J, Jackman, M P
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1132332/
https://ncbi.nlm.nih.gov/pubmed/8457193
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