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Targeting the Akt/mTOR pathway in Brca1-deficient cancers
The breast cancer susceptibility gene 1 (Brca1) has a key role in both hereditary and sporadic mammary tumorigenesis. However, the reasons why Brca1-deficiency leads to the development of cancer are not clearly understood. Activation of Akt kinase is one of the most common molecular alterations asso...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3107712/ https://ncbi.nlm.nih.gov/pubmed/21242970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.603 |
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