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Impaired Smad7-Smurf–mediated negative regulation of TGF-β signaling in scleroderma fibroblasts
The principal effect of TGF-β1 on mesenchymal cells is its stimulation of ECM synthesis. Previous reports indicated the significance of the autocrine TGF-β loop in the pathogenesis of scleroderma. In this study, we focused on Smad7 and Smurfs, principal molecules in the negative regulation of TGF-β...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC310747/ https://ncbi.nlm.nih.gov/pubmed/14722617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200416269 |
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