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Constitutive Thrombospondin-1 Overexpression Contributes to Autocrine Transforming Growth Factor-β Signaling in Cultured Scleroderma Fibroblasts
The extracellular matrix (ECM) glycoprotein thrombospondin-1 (TSP-1) has been reported to activate the latent complex of transforming growth factor-β (TGF-β), the major effects of which in mesenchymal cells is stimulation of the synthesis of ECM. Previous reports suggested the involvement of an auto...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Investigative Pathology
2005
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1606399/ https://ncbi.nlm.nih.gov/pubmed/15855645 |
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