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ATR mediates cisplatin resistance in a p53 genotype-specific manner
The protein kinase encoded by the ataxia-telangiectasia and Rad3-related (ATR) gene is activated by DNA damaging agents that are frequently employed as anticancer therapeutics. Inhibition of ATR expression in cultured cancer cells has been demonstrated to increase sensitivity to chemotherapeutic dru...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3107343/ https://ncbi.nlm.nih.gov/pubmed/21258400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.624 |
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