Cancer Stem Cells Contribute to Cisplatin Resistance in Brca1/p53–Mediated Mouse Mammary Tumors

The majority of BRCA1-associated breast cancers are basal cell–like, which is associated with a poor outcome. Using a spontaneous mouse mammary tumor model, we show that platinum compounds, which generate DNA breaks during the repair process, are more effective than doxorubicin in Brca1/p53–mutated...

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Hlavní autoři: Shafee, Norazizah, Smith, Christopher R., Wei, Shuanzeng, Kim, Yoon, Mills, Gordon B., Hortobagyi, Gabriel N., Stanbridge, Eric J., Lee, Eva Y-H. P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929908/
https://ncbi.nlm.nih.gov/pubmed/18451150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-5480
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