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Newcastle disease virus degrades HIF-1α through proteasomal pathways independent of VHL and p53

Newcastle disease virus (NDV) is a candidate agent for oncolytic virotherapy. Despite its potential, the exact mechanism of its oncolysis is still not known. Recently, we reported that NDV exhibited an increased oncolytic activity in hypoxic cancer cells. These types of cells negatively affect thera...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Gen Virol
Hauptverfasser: Abd-Aziz, Noraini, Stanbridge, Eric J., Shafee, Norazizah
Format: Artigo
Sprache:Inglês
Veröffentlicht: Microbiology Society 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5203671/
https://ncbi.nlm.nih.gov/pubmed/27902314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jgv.0.000623
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