DNA Damage Is a Prerequisite for p53-Mediated Proteasomal Degradation of HIF-1α in Hypoxic Cells and Downregulation of the Hypoxia Marker Carbonic Anhydrase IX

We investigated the relationship between the tumor suppressor p53 and the hypoxia-inducible factor-1 (HIF-1)-dependent expression of the hypoxia marker, carbonic anhydrase IX (CAIX). MCF-7 (wt p53) and Saos-2 (p53-null) cells displayed similar induction of CAIX expression and CA9 promoter activity u...

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Detalhes bibliográficos
Main Authors: Kaluzová, Milota, Kaluz, Stefan, Lerman, Michael I., Stanbridge, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC480909/
https://ncbi.nlm.nih.gov/pubmed/15199132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.13.5757-5766.2004
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