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Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9
The p53 gene has been implicated in many cancers due to its frequent mutations as well as mutations in other genes whose proteins directly affect p53’s functions. In addition, high expression of p53 [wild-type (WT) or mutant] has been found in the cytoplasm of many tumor cells, and studies have asso...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3575457/ https://ncbi.nlm.nih.gov/pubmed/23255126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.23054 |
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