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Fidelity and Mutational Spectrum of Pfu DNA Polymerase on a Human Mitochondrial DNA Sequence

The study of rare genetic changes in human tissues requires specialized techniques. Point mutations at fractions at or below 10(−6) must be observed to discover even the most prominent features of the point mutational spectrum. PCR permits the increase in number of mutant copies but does so at the e...

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Detaylı Bibliyografya
Asıl Yazarlar: André, Paulo, Kim, Andrea, Khrapko, Konstantin, Thilly, William G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 1997
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC310667/
https://ncbi.nlm.nih.gov/pubmed/9267808
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