Fidelity and Mutational Spectrum of Pfu DNA Polymerase on a Human Mitochondrial DNA Sequence

The study of rare genetic changes in human tissues requires specialized techniques. Point mutations at fractions at or below 10(−6) must be observed to discover even the most prominent features of the point mutational spectrum. PCR permits the increase in number of mutant copies but does so at the e...

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Pubblicato in:	Genome Res
Autori principali:	André, Paulo, Kim, Andrea, Khrapko, Konstantin, Thilly, William G.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 1997
Soggetti:	Genome Methods
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310667/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9267808/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gr.7.8.843
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