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Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors

NR4A1 (Nur77, TR3) is overexpressed in pancreatic tumors and activation of TR3 by 1,1-bis(3′-indolyl)-1-(p-methoxyphenyl)methane (DIM-C-pPhOCH(3)) inhibits cell and tumor growth and induces apoptosis. Microarray analysis demonstrates that in L3.6pL pancreatic cancer cells DIM-C-pPhOCH(3) induces gen...

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Detalhes bibliográficos
Main Authors: Yoon, Kyungsil, Lee, Syng-Ook, Cho, Sung-Dae, Kim, Kyounghyun, Khan, Shaheen, Safe, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3106434/
https://ncbi.nlm.nih.gov/pubmed/21362629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr040
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